Flunarizine inhibits endothelium-dependent hypoxic facilitation in canine coronary arteries through an action on vascular smooth muscle
نویسندگان
چکیده
منابع مشابه
Endothelium-Injured Canine Coronary Arteries
The goal of this study was to test the hypotheses that endogenous ADP plays an important role in vivo in mediating platelet aggregation and cyclic coronary artery blood flow variations (CFVs) in stenosed and endothelium-injured coronary arteries in an experimental canine model. Anesthetized animals were studied and coronary blood flow velocities monitored by a pulsed Doppler flow probe position...
متن کاملDevelopment of endothelium-dependent relaxation in canine coronary collateral arteries.
BACKGROUND Little information exists regarding development of vasomotor control mechanisms during coronary collateral artery maturation. Therefore, we studied endothelium-dependent relaxation of canine collateral arteries isolated 2, 4, and 9 months after placement of an ameroid occluder around the proximal left circumflex coronary artery. RESULTS Collateral arteries isolated after 2 months e...
متن کامل[Amiodarone causes endothelium-dependent vasodilation in canine coronary arteries].
OBJECTIVE To assess the vasodilating effects of amiodarone on canine coronary arteries by using solutions of amiodarone dissolved in polysorbate 80 or water. METHODS Rings of coronary arteries, with or without intact endothelium, were immersed in Krebs solution and connected to a transducer for measuring the isometric force promoted by a vascular contraction. The arteries were exposed to incr...
متن کامل48-h Hypoxic exposure results in endothelium-dependent systemic vascular smooth muscle cell hyperpolarization.
Chronic hypoxia (CH) results in reduced sensitivity to vasoconstrictors in conscious rats that persists upon restoration of normoxia. We hypothesized that this effect is due to endothelium-dependent hyperpolarization of vascular smooth muscle (VSM) cells after CH. VSM cell resting membrane potential was determined for superior mesenteric artery strips isolated from CH rats (PB = 380 Torr for 48...
متن کاملHypoxic Exposure Results In Persistent Endothelium - Dependent Systemic Vascular Smooth Muscle Cell
Chronic hypoxia (CH) results in reduced sensitivity to vasoconstrictors in conscious rats that persists upon restoration of normoxia. We hypothesized that this effect is due to endothelium-dependent hyperpolarization of vascular smooth muscle (VSM) cells following CH. VSM cell resting membrane potential was determined for superior mesenteric artery strips isolated from CH rats (PB = 380 torr; 4...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1988
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1988.tb11706.x